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A multi-kinase inhibitor inhibits FLT3 CSF1R c-Kit FGFR1 FGFR3 VEGFR1 -2 and -3 PDFGRa and PDGFRB (IC50s 1 36 2 8 9 10 13 8 27 and 210 nM respectively) inhibits the proliferation of human multiple myeloma cell lines expressing mutant but not wild-type FGFR3 (IC50s 90-550 and >2500 nM respectively) decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells at 500 nM inhibits bFGF-induced angiogenesis in a Matrigel™ plUG assay in mice at 3-300 mg/kg for 8 days reduces tumor growth in KM12L4A DU145 and MV4-11 mouse xenograft models (ED50s 17 23 and 3 mg/kg per day respectively)
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An antagonist of NR2B subunit-containing NMDA receptors (Ki 72 nM) selective for NR2B subunit-containing NMDA receptors over those containing NR2A subunits (IC50s 47 and 10000 nM respectively) reduces carrageenan-induced hyperalgesia in rats (ED50 5.5 mg/kg) reduces dopaminergic neuron loss in the rat substantia nigra pars compacta and improves measures of ipsilateral curling ipsilateral head positioning and beam walking in a rat model of 6-OHDA-induced Parkinsons disease at 10 mg/kg
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A phospholipid-porphyrin conjugate LNPs containing 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC and encapsulating FAM-labeled siRNA increase cytosolic siRNA levels 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC-stabilized nanoemulsions loaded with paclitaxel and combined with laser irradiation reduce tumor growth and increase survival in a KB squamous cell carcinoma mouse xenograft model
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Immunoassay Buffer C Concentrate (10X) has been formulated and tested to work with Cayman’s Assay Kits. Detailed instructions for its use are contained in the respective Cayman Assay Kit booklet.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Film can cling to itself and glass vessels. It is heat Resistant and softens at 100 degree C. It is strong and will stretch 300-400% before breaking or tearing. It is tight sealing and forms and air tight barrier when stretched across openings. Ideal for Test Tubes. Width: 1"
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More